bioinorganic chemistry @UBB

Welcome to Prof. Radu Silaghi-Dumitrescu's research group page at the Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University. We are an enthusiastic team focused on bioinorganic chemistry - and especially metalloproteins - at UBB since 2006.


We are interested especially in small molecule activation at bioinorganic systems containing transition metals (heme proteins, non-heme iron cobalamin, copper-containing proteins, model systems and others) as well as on oxidative/nitrosative stress especially when pertaining to bioinorganic centers and biologically-relevant free radical chemistry.


We typically employ methods such as UV-vis, EPR, stopped-flow, freeze-quench, molecular biology, protein overexpression and purification, as well as molecular modelling (DFT, semiempirical, molecular dynamics, docking and others).

Meet Our Team

Our main labs are in rooms 56 (stopped-flow, UV-vis, student office), 2 (EPR), and 80 (prof's office) at the Faculty of Chemistry and Chemical Engineering, UBB, downtown Cluj-Napoca.

11, Arany Janos,RO-400024 Cluj-Napoca; Romania

e-mail: radu.silaghi@ubbcluj.ro

http://www.chem.ubbcluj.ro/~rsd/

Fax: +40-264590818; Skype: radu.silaghidumitrescu

Tel: +40-264593833 ext. 5675; Mob: +40-741810819

  • Prof. Radu Silaghi-Dumitrescu
    Prof. Radu Silaghi-Dumitrescu received his PhD degrees from the University of Georgia in Athens, GA, U.S.A. (2004, experimental bioinorganic chemistry) and from the Babeș-Bolyai University in Romania (2005, computational inorganic chemistry). After a postdoctoral stage at the University of Essex (Colchester, England), he returned to the Babeș-Bolyai University in 2007, where he teaches biochemistry, computational chemistry and related subjects, while also serving as president of the Scientific Council (2012-) and director of the Center for University Strategies (2020-).
  • dr. Adrian MV Brânzanic
    Senior Researcher
    adrian.branzanic@ubbcluj.ro
    https://scholar.google.ro/citations?user=nEo0zQ0AAAAJ&hl=ro&oi=ao

    Dr. Adrian Brânzanic is a computational chemist with interest in cluster chemistry, bioinorganic centers and materials science.
  • Maria Lehene
    Maria studies reactions of cobalamin and of globins with small-molecule ligands, using UV-vis, stopped-flow, NMR, resonance Raman and fluorescence.
  • Cezara Zăgrean-Tuza
    Cezara's research projects have a focus on EPR spectroscopy but also include UV-vis, stopped-flow, NMR and other methods. Her targets include plant globins, cytochrome P450 and others.
  • Radu Onija
    MSc student
    Radu is a first-year MSc student with prior experience in organic synthesis for solar cell applications.
  • Rami Doukeh
    Rami is a lecturer at the Petroleum-Gas University of Ploiești and pursues a second PhD degree in our group, focused on small molecule activation with metal-based catalysts with industrial applications.
  • Oleg Rudenco
    PhD student
    oleg.rudenco@stud.ubbcluj.ro
    https://www.webofscience.com/wos/author/record/41550981
    Oleg has graduated his MSc studies working on the reactivity of thiourea dioxide versus biological centers, using UV-vis, NMR and DFT calculations. He is now working jointly with Prof. Alexandru Lupan on a PhD project involving computational chemistry approaches to cluster chemistry.
  • George Vaida
    PhD student
    george.vaida@stud.ubbcluj.ro
    George follows up on undergraduate studies on biology and law, and on an MSc degree in forensic chemistry.
  • Alexandru Sonica
    MSc student
    alexandru.sonica@stud.ubbcluj.ro
    Alex is a first-year MSC student working on the interactions of hemoglobin and its redox interactions.
  • Theodor Dănescu
    PhD student
    theodor.danescu@ubbcluj.ro
    https://scholar.google.com/citations?hl=en&user=oRwAeb4AAAAJ
    Theodor has been working with Prof. Alexandru Lupan for his BSc and MsC projectS involving computational chemistry approaches to cluster chemistry. He will be working with dr. Vlad Cojocaru and Andreas Bender on applications of computational chemistry in biosciences.
  • Szilárd Pesek
    Szilárd teaches chemistry and serves as Principal of the Leőwey Klára high-school in Sighetu Marmației, while also studying for his PhD on computational chemistry applications in biomolecules.
  • Lavinia Pădurean
    MSc student
    giorgiana.padurean@stud.ubbcluj.ro
    Lavinia is a BSc student studying the reactivity of ferryl states in heme proteins.
  • József Simon
    MSc student
    jozsef.simon@stud.ubbcluj.ro
    József is wrote his undergraduate diploma paper on the interactions of blood substitute candidates with antioxidants, using spectroscopic methods. He is now pursuing this topic for his MSc dissertation.
  • Nicoleta Andrian
    MSc student
    nicoleta.andrian@stud.ubbcluj.ro
    Nicoleta is a first-year MSc student in clinical chemistry.
  • Sergiu-Raul Cosma
    MSc student
    sergiu.cosma@stud.ubbcluj.ro
    Raul defended his diploma paper for his BSc studies with DFT computations on the chlorite dismutase mechanism. He is now pursuing his studies for an MSc degree with focus on QM/MM applications.
  • Andrea Incze
    MSc student
    andrea.incze@stud.ubbcluj.ro
    Andrea got her BSc degree in genetic engineering at the Sapientia – Hungarian University of Transylvania and is now a first-year MSc student in forensic chemistry,
  • Other students



    A number of other students do occasional internships in our group. We also welcome occasional visitors.
A few of our current research projects:
Blood Substitutes
The blood currently used in transfusions presents problems linked to stability (requiring refrigeration and becoming outdated after about a month), availability (especially under crisis situations, such as major accidents, military situations, or major outbreaks), antigens (blood group compatibility), contamination (AIDS, hepatitis, or agents yet to be identified) or ethics (e.g., Jehovah's witnesses). Blood substitutes are chemical or biochemical preparations aimed at being used in transfusions without the above-mentioned drawbacks and with the sole role of enhancing oxygen transport by the patient's blood (as opposed to the more complex functions that blood normally achieves, such as transport or defense).

There are three classes of blood substitutes currently being debated in the scientific literature. The first two classes represent purely synthetic approaches, while the third is semi synthetic, employing the hemoglobin already produced by living organisms. We have recently added a fourth class of blood substitutes, whose active ingredient is also a protein specialized in oxygen transport, but of non-heme nature: hemerythrin (Hr). Hr employs a binuclear non-heme diferrous center to bind oxygen; the resulting adduct is formally described as Fe(III)-Fe(III)-OOH, i.e. diferric peroxo. This mode of binding oxygen has the remarkable advantage of (1) not featuring a superoxide ligand (unlike Hb), which drastically reduces the reactivity towards NO, and (2) exhibiting stability towards peroxide (unlike Hb).

Anticancer Drugs
Cisplatin and related compounds are known to exert much of their useful therapeutic effects via binding to DNA. The need for more effective drugs as well as the wide range of side-effects (nausea, progressive peripheral sensory neuropathy, fatigue, vomiting, alopecia, hematological suppression, renal damage) have, for several decades now, fueled interest into understanding the complex mechanisms of interaction of cisplatin and related compounds with various biomolecules. One notable observation in this respect has been that platinum can bind to a range of proteins, as demonstrated by elemental analyses, chromatography and mass spectrometry. Our own research, with established as well as with experimental drugs, including natural extracts of various sources, is seeking to investigate the free-radical mechanisms involved in such drug-protein interactions, with purified proteins as well as with intact cells.

Small Molecule Activation at Biological Complexes (high-valent and super-reduced centers; linkage isomerism)
Reduction of nitrite to nitric oxide is essential in certain living species, and has recently been proposed to be an important secondary function of hemoglobin in humans. In vivo, nitrite reduction is accomplished by metalloenzymes, involving direct metal-nitrite coordination. We proposed that linkage nitro/nitrito isomerism is an essential part of the mechanism in copper and in heme d1-containing nitrite reductases. Recent experimental work has also shown involvement of linkage isomerism in catalytic reduction of nitrite by free hemes and related small complexes in solution. This mechanism reconciles the cd1NIR chemistry with the puzzling fact that Fe(III)-NO is kinetically inert and hence cannot possibly be a part of the cd1NIR catalytic cycle.

Proteins such as cytochrome P450 (P450), horseradish peroxidase (HRP), hemoglobin and catalase are all known to bind and/or ruduce (activate) dioxygen at their heme active sites, in the ferrous form. Our interest has been in defining the properties and reactivity of the transient adducts (nature of ferrous-dioxygen bonding, nature of ferric-peroxo interaction, electronic structure and protonation state of ferryl, i.e. Compounds I and II).

We are also pursuing the related reactions of heme systems with sulfide and sulfur oxyanions (e.g., sulfite reductase and sulfhemoglobin chemistry), as well as with halide oxyanions (relevant to myeloperoxidase, chlorite discutase and others). We have more recently extended this line towards other transition metal - containing macrocyclic complexes, such as cobalamin, porphyrazines and phthalocyanines. In such systems, unusual metal oxidation states (e.g., Fe(IV), Fe(I), Fe(0), Co(I)) under physiologically-relevant conditions are a common theme.

Laccase (p-diphenol:dioxygen oxidoreductase), one of the oldest discovered enzymes, contains four copper ions in two active sites and catalyzes a monoelectronic oxidation of substrates such as phenols and their derivatives, or aromatic amines, coupled to a four-electron reduction of dioxygen to water. The catalytic mechanism was studied for decades but is still not completely elucidated, especially in terms of the reduction of dioxygen to water. The high interest in laccases is explained by the large number of biotechnological applications. We have purified and characterized laccase-type enzymes, with interest in their applications as well as in further understanding their mechanisms of action.


Polyoxometalates (POMs) comprise a rich and diverse family of metal-oxygen clusters of the early transition metals in high oxidation states, most commonly V(V), Mo(VI) and W(VI), with unique versatility in terms of shape, polarity, redox potentials, surface charge distribution, acidity, and solubility. We are analyzing iron-substituted POMs in search of features common with/reminiscent of those seen in iron-based redox metalloenzymes.

Molecular Modelling of Biopolymers
We are investigating preferences for various types of secondary structure, and tools for predicting three-dimensional structures in peptides and in other biopolymers, such as polylactic acid and polymers relevant in dental materials.

Natural Extracts
We are examining plant extracts, fungi, food- or drug-related components, or other natural products, for their antioxidant and biological activity (anticancer, etc.), with emphasis on chemical mechanisms of their action.

Cultural Studies
We are also pursuing the application of chemical and biochemical concepts in social/cultural studies.

Alumni


PhD students

Augustin Moț, Florina Deac (Scurtu), Cristina Bischin, Izabella Irsai, Mihai Surducan, Amr Attia, Francisco Carrascoza, Luana Radu, Adrian Branzanic, Alina Matei, Radu Catana


Undergraduates and MSc

Diana Plesa, Victoria Cirjeu, Bianca Caba, Norbert Szabó, Ilinca Igescu, Flavia Oana, Iulia Bercea, Mara Lala, Maria Popa, Catalina Barcaru, Artiom Gaina-Gardiuta, Bogdan Timisag, Iulia Patrascu, Nicoleta Tomoioaga, Bianca Popus, Lavinia Ungureanu, Biborka Boga, Vicentiu Taciuc, Rebeca-Oana Grecu, Karina Malearciuc, Anca Anghel, Alexandra Serban, Alexandra-Domnica Magdici, Madalina Raiu, Diana-Dana Toth, Alina Mircea, Adriana Andonie, Patricia Miclea, Vlad Toma, Anca Farcas, Tünde Evelin Takács, Hilda Timea Pato, Kinga Szabo, Flavia-Luana Radu, Daniela Craciun, Oana Cristina Rus, Camelia Tusan, Flavia Rakoczi, Adela Marina Covaciu, Adrian Ionele, Alexandra Simon, Andreea-Ancuţa Bujdei, Denisa Hathazi, Daniela Cioloboc, Sonia Diana Mahut, Cristina – Izabella Berci, Anetta Vaida, Diana Hotea, Claudia Pasc, Alina M. Crainic, Carmen-Elena Miron, Raluca Florina Mătieş, Ancuta Teodora Tomolea, Bianca Marcela Mureşan, Bernadett-Edina Vitek-Daroczi, Daliana-Camelia Şimon, Cristina Miron, Andreea Bob, Antonela Camelia Botiş, Anamaria Felicia Popa, Camelia Clenci, Ciprian Cosar, Bianca Alexandra Iacob, Anamaria Popa, Bianca Marcela Mureşan, Gabriela Daniela Contra, Ioana-Alexandra Suciu, Anita Papp, Anamaria Imre, Csongor Matyas, Dorina Lup, Agnes Kozma, Roxana-Viruca Ţolan, Oana Cristina Rus, Mariann-Kinga Arkosi, Cristina Dobie, Oana Zolog, Ioana Andreea Todea, Alina Roman, Stanca Boboia, Anamaria Todea, Ana-Maria Bolfa, Zoltan Kis, Laszlo Ajtai, Irina Ciotlaus, Angela Sas, Liana Tamas

Our scientific publications in journals and conference proceedings:
302. Stoean, Bianca; Lupan, Iulia; Cristea, Castelia; Silion, Mihaela; Silaghi-Dumitrescu, Luminita; Silaghi-Dumitrescu, Radu; Gaina, Luiza Ioana. Outcomes of folic acid esterification upon the properties of hydrophilic phenothiazinium dyes: New photosensitizers for antimicrobial photodynamic therapy. Journal of Photochemistry and Photobiology A: Chemistry, 2023, 115500. https://doi.org/10.1016/j.jphotochem.2024.115500
301. Pesek, Szilard; Silaghi-Dumitrescu, Radu. The Iodine/Iodide/Starch Supramolecular Complex. Molecules, 2024, 29(3), 641. https://doi.org/10.3390/molecules29030641
300. Silaghi-Dumitrescu, Radu. The king, the communists and the roman blood: an automated analysis of the Romanian national anthems. Proglas, 2023, 32(2), 147-157. https://doi.org/10.54664/GGAE2354.
299. Benedec, Daniela; Oniga, Ilioara; Hanganu, Daniela; Tiperciuc, Brîndușa; Nistor, Adriana; Vlase, Ana-Maria; Vlase, Laurian; Pușcaș, Cristina; Duma, Mihaela; Login, Cristian Cezar; Mihaela Niculae, Silaghi-Dumitrescu, Radu. Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential. Antibiotics, 2013, 12(11), 1644. https://doi.org/10.3390/antibiotics12111644.
298. Dănescu, Theodor; Lupan, Alexandru; Silaghi-Dumitrescu, Radu; King, R. Bruce. Theoretical Study of the Effect of Phosphorus and Nitrogen Heteroatoms on Pentahapto Coordination of Diazaphospholyl Ligands in Binuclear Ruthenium and Iron Carbonyl Derivatives. Journal of Organometallic Chemistry, 2023, 122949. https://doi.org/10.1016/j.jorganchem.2023.122949.
297. Coman, Cristina; Hadade, Niculina; Pesek, Szilard, Silaghi-Dumitrescu, Radu; Mot, Augustin C. Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase. Journal of Inorganic Biochemistry, 2023, 112400. https://doi.org/10.1016/j.jinorgbio.2023.112400.
296. Fischer-Fodor, Eva; Szabo, Kinga; Scurtu, Florina; Lehene, Maria; Silaghi-Dumitrescu, Radu. Toxicity of hemoglobin derivatized with oxidized adenosine triphosphate against tumoral human cells. Studia UBB Chemia, 2023, LXVIII(3), 153-160. DOI:10.24193/subbchem.2023.3.10.
295. Lehene, Maria; Zagrean-Tuza, Hadade, Niculina; Cezara; Aghion, Andreea; Septelean, Raluca; Iancu, Stefania; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. A complex of cobalamin with an organic peroxide. New Journal of Chemistry, 2023, . https://doi.org/10.1039/D3NJ03307D.
294. Silaghi-Dumitrescu, Radu. Trends in the Texts of National Anthems: A Comparative Study. Heliyon, 2023 e19105. https://doi.org/10.1016/j.heliyon.2023.e19105.
293. Silaghi-Dumitrescu, Radu; Patrascu, Iulia; Lehene, Maria; Bercea, Iulia. Comorbidities of COVID-19 Patients. Medicina, 2023, 59(8), 1393. https://doi.org/10.3390/medicina59081393.
292. Doukeh, Rami; Craciun, Daniela; Lupan, Alexandru; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. Effect of the coordination environment on the ability of iron to bind/activate N2: a theoretical study with relevance to the nitrogenase mechanism. Polyhedron, 2023, 116571. DOI: 10.1016/J.POLY.2023.116571.
291. Lehene, Maria; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. The adducts of cyano- and aquacobalamin with hypochlorite. Journal of Biological Inorganic Chemistry, 2023, doi: 10.1007/s00775-023-02015-z.
290. Plesa, Diana; Lehene, Maria; Silaghi-Dumitrescu, Radu. On the reaction of Co(II) cobalamin with hydrogen peroxide. Reaction Kinetics, Mechanisms and Catalysis, 2023, https://doi.org/10.1007/s11144-023-02441-9.
289. Irsai, Izabella; Pesek, Szilard, Silaghi-Dumitrescu, Radu. A critical review of computational efforts towards identifying secondary structure elements in polylactic acid (PLA). Revue Roumaine de Chimie, 2023, in press.
288. Gaina-Gardiuta, Artiom; Lupan, Alexandru; Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. Study of cobalamin adducts with cysteine and its oxidized sulfenic, sulfinic and sulfonic derivatives. Revue Roumaine de Chimie, 2023, 3-4, 143-151, DOI: 10.33224/rrch.2023.68.3-4.04.
287. Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. Quale Mechanics as a Metaphysical Weltanschauung of Quantum Mechanics. History of science and technology, 2023, 13(1), 10-33, DOI: 10.32703/2415-7422-2023-13-1-10-33.
286. Arkosi, Mariann-Kinga; Mot, Augustin C.; Lupan, Iulia; Ghinia Tegla, Miruna Georgiana; Silaghi-Dumitrescu, Radu. Selective attachment of polyethylene glycol to hemerythrin for potential use in blood substitutes. Protein Journal, 2023, https://doi.org/10.1007/s10930-023-10118-4.
285. Rudenco, Oleg; Lehene, Maria; Lupan, Alexandru; Zagrean-Tuza, Cezara; Stoean, Bianca; Gaina-Gardiuta, Artiom; Ulici, Adelina Maria; Silaghi-Dumitrescu, Radu. Versatility of thiourea dioxide as redox agent in globins: case study with myoglobin. Inorganica Chimica Acta, 2023, 121474; https://doi.org/10.1016/j.ica.2023.121474.
284. Stoica, Anca D.; Toma, Vlad-Al.; Roman, Ioana; Sevastre, Bogdan; Scurtu, Florina; Silaghi-Dumitrescu, Radu. Glutaraldehyde-polymerized hemerythrin: evaluation of performance as an oxygen carrier in hemorrhage models. Bioinorganic Chemistry and Applications, 2022, 2209101; https://doi.org/10.1155/2022/2209101.
283. Pesek, Szilard, Lehene, Maria; Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. On the origin of the blue color in the iodine / iodide / starch supramolecular complex. Molecules, 2022, 27(24), 8974; https://doi.org/10.3390/molecules27248974.
282. Pesek, Szilard, Silaghi-Dumitrescu, Radu. Polylactic acid inter-chain interactions. Studia Universitatis Babes-Bolyai Seria Chemia, 2022, LXVII, 47-71 ; DOI:10.24193/subbchem.2022.4.04.
281. Stoean, Bianca; Gaina, Luiza; Cristea, Castelia; Silaghi-Dumitrescu, Radu; Branzanic, Adrian M. V.; Focsan, Monica; Fischer-Fodor, Eva; Tigu, Bogdan; Moldovan, Cristian; Cecan, Andra Diana; Achimas-Cadariu, Patriciu; Astilean, Simion; Silaghi-Dumitrescu Luminita. New methylene blue analogues with N-piperidinyl-carbinol units: Synthesis, optical properties and in vitro internalization in human ovarian cancer cells. Dyes and Pigments, 2022, https://doi.org/10.1016/j.dyepig.2022.110460.
280. Osokin, Vladimir S.; Dereven’kov, Ilia A.; Makarov, Sergei V.; Gaina-Gardiuta, Artiom; Silaghi-Dumitrescu, Radu. Effect of trans-ligand on properties of nitric oxide motif in nitrosylcobinamide.
Journal of Coordination Chemistry, 2022, DOI: 10.1080/00958972.2022.2079409.
279. Carrascoza, Francisco; Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. The dynamics of hemerythrin and hemerythrin derivatives. Studia Universitatis Babes-Bolyai Seria Chemia, 2021, 64(4), 397-404.
278. Dănescu, Theodor; Silaghi-Dumitrescu, Radu; Lupan, Alexandru; King R Bruce. Cyclopentadienylmetal group 6 carbonyl derivatives with 2-propanoneoximato and related ligands. New Journal of Chemistry, 2021, https://doi.org/10.1039/D1NJ04379J.
277. Suciu, Ioana-Alexandra; Lupan, Alexandru; Silaghi-Dumitrescu, Radu. Peroxo-transition metal systems: examples of redox Isomerism in palladium structure. Revue Roumaine de Chimie 2021, 66(10-11), 811–820. 10.33224/rrch.2021.66.10-11.04.
276. Mazilu (Moldovan), Amalia; Popescu, Violeta; Sarosi, Codruta; Silaghi-Dumitrescu, Radu; Chisnoiu, Andrea Maria; Moldovan, Marioara; Silaghi Dumitrescu, Laura; Prodan, Doina; Carpa, Rahela; Gheorghe, Georgiana Florentina; Chisnoiu, Radu Marcel. Preparation and in vitro characterization of gels based on bromelain, whey and quince extract. Gels, 2021, 7, 191. https://doi.org/10.3390/gels7040191.
275. Lehene, Maria; Plesa, Diana; Ionescu-Zinca, Stefania; Iancu, Stefania D.; Leopold, Nicolae; Makarov, Sergei V.; Brânzanic, Adrian M.V.; Silaghi-Dumitrescu, Radu. Adduct of aquacobalamin with hydrogen peroxide. Inorganic Chemistry, 2021, 60(17), 12681-12684.
274. Irsai, Izabella; Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. Polylactic acid interactions with bioceramic surfaces. Studia Universitatis Babes-Bolyai Seria Chemia, 2021, 66(3), 107-121.
273. Carrascoza, Francisco; Silaghi-Dumitrescu, Radu. The dynamics of hemoglobin-haptoglobin complexes. Relevance for oxidative stress. Journal of Molecular Structure, 2022, 1250(1), 131703.
272. Cîrjeu, Victoria; Pușcaș, Cristina; Silaghi-Dumitrescu, Radu. Vincristine affects the redox reactivity of hemoglobin. Studia UBB Chemia, 2021, in press.
271. Silaghi-Dumitrescu, Radu. Measuring pseudoscience in online media: a case study on Romanian websites. Journal of Romanian Studies, 2021, in press.
270. Dereven’kov, Ilia A.; Makarov, Sergei V; Branzanic, Adrian; Silaghi-Dumitrescu, Radu; Molodtsov, Pavel A.; Pokrovskaya, Elizaveta A.. Formation of hydroxyl radical in aqueous solutions containing selenite and glutathione. Polyhedron, 2021, 115072.
269. Radu, Luana; Attia, Amr A.; Silaghi-Dumitrescu, Radu; Lupan, Alexandru; King, R. Bruce. Binuclear ethylenedithiolate iron carbonyls: a density functional theory study. Inorganica Chimica Acta, 2021, 120260.
268. Silaghi-Dumitrescu Radu. Topics in National Anthems. Journal of Language and Literature, 2020, 20(2), 288-306, http://dx.doi.org/10.24071/joll.v20i2.2541.
267. Silaghi-Dumitrescu Radu; Gruian, Cristina; Puscas, Cristina; Simon, Alexandra; Fischer-Fodor, Eva; Toma, Vlad Al.; Farcas, Anca D.; Roman, Ioana; Scurtu, Florina; Attia, Amr A.A.; Damian, Grigore. Spin labelled hemoglobin-based oxygen carriers (HBOC): preparation and evaluation of in vivo/in vitro stability. Studia UBB Chemia, 2020, 65(2), 121-132.
266. Lehene, Maria; Fischer-Fodor, Eva; Scurtu, Florina; Hadade, Niculina; Mot, Augustin C.; Gal, Emese; Matei, Alina; Silaghi-Dumitrescu Radu. Excess ascorbate is a chemical stress agent against proteins and cells. Pharmaceuticals, 2020, 13(6): 107, doi.org/10.3390/ph13060107.
265. Farcas, Anca D.; Toma, Vlad Al.; Roman, Ioana; Sevastre, Bogdan; Scurtu, Florina; Silaghi-Dumitrescu, Radu. Glutaraldehyde-polymerized hemoglobin: in search of improved performance as oxygen carrier in hemorrhage models. Bioinorganic Chemistry and Applications, 2020, 1096573, doi.org/10.1155/2020/1096573.
264. Matei, Alina; Puscas, Cristina; Patrascu, Iulia; Lehene, Maria; Ziebro, Julia; Scurtu, Florina; Baia, Monica; Porumb, Dan; Totos, Robert; Silaghi-Dumitrescu Radu. On the stability of glutaraldehyde in biocide compositions. International Journal of Molecular Sciences, 2020, 21(9): 3372.
263. Carrascoza, Francisco; Surducan, Mihai; Eriksson, Leif; Silaghi-Dumitrescu, Radu. Interaction of cobalt and iron hydroperoxo bleomycin with deoxyribonucleic acid (DNA): dynamic vs. electronic structure considerations. Inorganica Chimica Acta, 2020, 119682.
262. Obasi, Titus Chukwuemeka; Benedec, Daniela; Hanganu, Daniela; Gheldiu, Anamaria; Vlase, Laurian; Oniga, Ilioara; Pușcaș, Cristina; Silaghi-Dumitrescu, Radu; Oprean, Radu. Free radical scavenging activity and total polyphenol content of Securidaca longipedunculata roots and leaves extracts. Farmacia, 2020, 68(1), 116-120.
261. Puscas, Cristina; Moldovan, Marioara; Silaghi-Dumitrescu, Laura; Ungureanu, Lavinia; Silaghi-Dumitrescu Radu. On the apparent redox reactivity of “oxygen-enriched water”. Biological Trace Element Research, 2020, 198, 350–358. doi.org/10.1007/s12011-020-02056-4.
260. Silaghi-Dumitrescu, Radu. Redox reactivity in globins: modulation by covalent and non-covalent modifications with biomedical relevance. Journal of Experimental and Molecular Biology, 2019, XX(3), 1-2.
259. Attia, Amr A.; Lupan, Alexandru; Silaghi-Dumitrescu, Radu; King, R. Bruce. Neutral rhenadicarbaboranes with Re(CO)2(NO) vrtices: a theoretical Study of building blocks for rhenacarborane-based drug delivery agents. Molecules, 2019, 25(1), E110.
258. Branzanic, Adrian; Ryde, Ulf; Silaghi-Dumitrescu, Radu. Importance of the iron–sulfur component and of the siroheme modification in the resting state of sulfite reductase. Journal of Inorganic Biochemistry, 2019, 110928.
257. Mot, Augustin C.; Coman, Cristina; Hadade, Niculina; Damian, Grigore; Silaghi-Dumitrescu, Radu; Heering, Hendrik A. “Yellow” laccase from Sclerotinia sclerotiorum is a blue laccase that enhances its substrate affinity by forming a reversible tyrosyl-product adduct. PLoS One, 2019, 0225530.
256. Branzanic, Adrian; Ryde, Ulf; Silaghi-Dumitrescu, Radu. Why does sulfite reductase employ siroheme? Chemical Communications, 2019, 55, 14047-14049.
255. Hanganu, Daniela; Olah, Neli-Kinga; Pop, Carmen; Vlase, Laurian; Oniga, Ilioara; Ciocarlan, Nina; Matei, Alina; Puscas, Cristina; Silaghi-Dumitrescu, Radu; Benedec, Daniela. Evaluation of polyphenolic profile and antioxidant Activity for some Salvia species. Farmacia, 2019, 67(5), 801-805. https://doi.org/10.31925/farmacia.2019.5.8
254. Hannibal, Luciana; Molodtsov, Pavel; Branzanic, Adrian; Silaghi-Dumitrescu, Radu; Makarov, Sergei. Kinetic, spectroscopic and in silico characterization of the first step of the reaction between glutathione and selenite. Inorganica Chimica Acta, 2020, 499, 119215.
253. Moldovan, Mirela L.; Iurian, Sonia; Puscas, Cristina; Silaghi-Dumitrescu, Radu; Hanganu, Daniela; Bogdan, Catalina; Vlase, Laurian; Oniga, Ilioara; Benedec, Daniela. A design of experiments strategy to enhance the recovery of polyphenolic compounds from Vitis vinifera by-products through heat reflux extraction. Biomolecules, 2019, 9(10), 529; https://doi.org/10.3390/biom9100529.
252. Farcas, Anca Daniela; Mot, Augustin C.; Zagrean-Tuza, Cezara; Ticolea, Madalina; Sevastre, Bogdan; Kulak, Muhittin; Silaghi-Dumitrescu Radu, Parvu, Alina. Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats. BMC Complementary and Alternative Medicine, 2019, 19, 289.
251. Sacalis, Carmen; Morar, Cristina; Lameiras, Pedro; Lupan, Alexandru; Silaghi-Dumitrescu, Radu; Bende, Attila; Katona, Gabriel; Porumb, Dan; Harakat, Dominique; Gál, Emese; Darabantu, Mircea. Design, synthesis and structure of novel dendritic G-2 melamines comprising piperidine motifs as key linkers and 4-(n-octyloxy)aniline as a peripheral unit. Tetrahedron, 2019, 75, 130468, https://doi.org/10.1016/j.tet.2019.130468.
250. Radu, Luana; Attia, Amr A.; Silaghi-Dumitrescu, Radu; Lupan, Alexandru; King, R. Bruce. The group 9 cyclopentadienylmetal cis ethylenedithiolates as metallodithiolene ligands in metal carbonyl chemistry: analogies to benzene metal carbonyl complexes. New Journal of Chemistry, 2019, 43(32), 12711-12718.
249. Puscas, Cristina; Mircea, Alina; Raiu, Madalina; Mic, Mihaela; Attia, Amr A. A.; Silaghi-Dumitrescu Radu. Affinity and effect of anticancer drugs on the redox reactivity of hemoglobin. Chemical Research in Toxicology, 2019, 32(7), 1402-1411.
248. Mot, Augustin C.; Puscas, Cristina; Dorneanu, Sorin; Silaghi-Dumitrescu Radu. Isolation, purification and characterization of ascorbate oxidase and peroxidase from Cucurbita pepo medullosa. Studia Universitatis Babes-Bolyai Seria Chemia, 2019, 64(2), 49-60.
247. Scurtu, Florina; Tebrean, Bogdan; Árkosi, Mariann Kinga; Ionele, Adrian; Silaghi-Dumitrescu, Radu. Hemoglobin-albumin co-polymers for blood substitutes: increasing the reproducibility of the polymerization reaction. Studia Universitatis Babes-Bolyai Seria Chemia, 2019, 64(2), 421-434.
246. Mot, Augustin C; Puscas, Cristina; Dorneanu, Sorin; Silaghi-Dumitrescu Radu. EPR detection of sulfanyl radical during sulfhemoglobin formation–Influence of catalase. Free Radical Biology and Medicine, 2019, 137, 110-115.
245. Radu, Luana; Attia, Amr A.; Silaghi-Dumitrescu, Radu; Lupan, Alexandru; King, R. Bruce. Reversible complexation of ammonia by breaking a manganese-manganese bond in a manganese carbonyl ethylenedithiolate complex: a theoretical study of an unusual type of Lewis acid. Dalton Transactions, 2019, 48, 324-332.
244. Turcas, Ramona; Kripli, Balázs; Attia, Amr A. A.; Lakk-Bogáth, Dóra; Speier, Gábor; Giorgi, Michel; Silaghi-Dumitrescu, Radu; Kaizer, József. Catalytic and stoichiometric flavanone oxidation mediated by nonheme oxoiron (IV) complexes as flavone synthase mimics: kinetic, mechanistic and computational studies. Dalton Transactions, 2018, 47, 14416-14420.
243. Puscas, Cristina; Radu, Luana; Carrascoza, Francisco; Mot, Augustin C; Amariei, Diana; Lungu, Oana; Scurtu, Florina; Podea, Paula; Septelean, Raluca; Matei, Alina; Mic, Mihaela; Attia, Amr A.; Silaghi-Dumitrescu Radu. The high affinity of small-molecule antioxidants for hemoglobin. Free Radical Biology and Medicine, 2018, 124, 260-274.
242. Oniga, Ilioara; Pușcaș, Cristina; Silaghi-Dumitrescu, Radu; Olah, Neli-Kinga; Sevastre, Bogdan; Marica, Raluca; Marcus, Ioan; Sevastre-Berghian, Alexandra; Benedec, Daniela; Pop, Carmen; Hanganu Daniela. Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies. Molecules, 2018, 23(8), 2077.
241. Mot, Augustin C; Puscas, Cristina; Miclea, Patricia; Naumova-Letia, Galaba; Dorneanu, Sorin; Podar, Dorina; Dissmeyer, Nico; Silaghi-Dumitrescu Radu. Redox control and autoxidation of class 1, 2 and 3 phytoglobins from Arabidopsis thaliana. Scientific Reports, 2018, 8(1), 13714.
240. Joy, Syed RU; Eszter, Trufan; Smith, Mark D.; Puscas, Cristina; Silaghi-Dumitrescu, Radu; Semeniuc, Radu F. An unexpected μ4-oxido-bridged tetranuclear Cu(II) inverse coordination complex of a heptadentate bis(pyrazolyl)methane-based ligand: Synthesis, structure, spectroscopic properties, and catecholase activity. Inorganica Chimica Acta, 2018, 485, 190-199.
239. Benedec, Daniela; Oniga, Ilioara; Hanganu, Daniela; Gheldiu, Ana Maria; Pușcaș, Cristina; Silaghi-Dumitrescu, Radu; Duma, Mihaela; Tiperciuc, Brîndușa; Vârban, Rodica; Vlase, Laurian. Sources for developing new medicinal products: biochemical investigations on alcoholic extracts obtained from aerial parts of some Romanian Amaryllidaceae species. BMC Complementary and Alternative Medicine, 2018, 18(1), 226.
238. Kostadinovic Velickovska, Sanja; Naumova Letia, Galaba; Cocevska, Maja; Bruhl, Ludger; Silaghi-Dumitresu, Radu; Mirhosseini, Hamed; Ilieva, Fidanka; Mihajlov, Ljupco; Dimovska, Violeta; Kovacevic, Biljana; Gulaboski, Rubin; Matthaus, Bertrand. Effect of bioactive compounds on antiradical and antimicrobial activity of extracts and cold-pressed edible oils from nutty fruits from Macedonia. Journal of Food Measurement and Characterization, 2018, 12, 1-8. 10.1007/s11694-018-9871-8
237. Farcas, Anca Daniela; Mot, Augustin C.; Zagrean-Tuza, Cezara; Toma, Vlad; Cimpoiu, Claudia; Hosu, Anamaria; Parvu, Marcel; Roman, Ioana; Silaghi-Dumitrescu, Radu. Chemo-mapping and biochemical-modulatory and antioxidant/prooxidant effect of Galium verum extract during acute restraint stress in female rats. PLoS One, 2018, 13(7), e0200022.
236. Surducan, Mihai; Branzanic, Adrian; Silaghi-Dumitrescu, Radu. Heme Fe-SO2- intermediates in sulfite reduction: contrasts with Fe-OO2- species from oxygen-oxygen bond activating systems. International Journal of Quantum Chemistry, 2018, 118(19), e25697.
235. Hathazi, Denisa; Scurtu, Florina; Bischin, Cristina; Mot, Augustin; Attia, Amr A. A.; Kongsted, Jacob; Silaghi-Dumitrescu, Radu. The reaction of oxy hemoglobin with nitrite: mechanism, antioxidant-modulated effect, and implications for blood substitute evaluation. Molecules, 2018, 23(2), E350. doi: 10.3390/molecules23020350.
234. Kostadinovic Velickovska, Sanja; Mot, Augustin C.; Mitrev, Sasa; Gulabovski, Rubin; Bruhl, Ludger; Mirhosseini, Hamed; Silaghi-Dumitresu, Radu; Matthaus, Bertrand. Bioactive compounds and ‘‘in vitro’’ antioxidant activity of some traditional and non-traditional cold-pressed edible oils from Macedonia. Journal of Food Science and Technology, 2018, 55(5),1614–1623.
233. Silaghi-Dumitresu, Radu; Tomoioagă, Nicoleta; Jurco, Eugen. Variability in biochemical composition of milk among three representative breeds of dairy cows from Romania. Studia Universitatis Babes-Bolyai Seria Chemia, 2018, LXIII, 55-62.
232. Irsai, Izabella; Lupan, Alexandru; Majdik, Cornelia; Silaghi-Dumitrescu, Radu. Computational investigation of spectroscopic parameters in putative secondary structure elements for polylactic acid and comparison with experiment. Studia Universitatis Babes-Bolyai Seria Chemia, 2017, LXII(4), 495-513.
231. Bischin, Cristina; Contra, Gabriela; Tusan, Camelia; Miclea, Patricia; Taciuc, Vicentiu; Parvu, Marcel; Silaghi-Dumitrescu, Radu. Free-radical reactions: the fine line between the anti- and pro-oxidant reactivities. Oxidation Communications, 2018, 41(1), 130–140.
230. Silaghi-Dumitrescu, Radu. “Compulsory prison for all”: an ironically-proposed rite of passage in a post-communist country. Journal of Media Critiques 2017, 12(3), 51-58.
229. Attia, Amr A. A.; Silaghi-Dumitrescu, Radu. Nickel-substituted iron dependent cysteine dioxygenase: implications for the dioxygenation activity of nickel model compounds. International Journal of Quantum Chemistry, 2018, 118(13), e25564.
228. Scurtu, Florina; Popa, Anamaria; Silaghi-Dumitrescu, Radu. Periodate-oxidized alginate as polycondensation reagent for hemoglobin. Studia Universitatis Babes-Bolyai Seria Chemia, 2017, LXII(4), 59-66.
227. Mot, Augustin; C.; Bischin, Cristina; Damian, Grigore; Attia, Amr A.A.; Gal, Emese; Dina, Nicoleta E.; Leopold, Nicolae; Silaghi-Dumitrescu, Radu. Fe(III) – sulfide interaction in globins: characterization and quest for a putative Fe(IV)-sulfide species. Journal of Inorganic Biochemistry, 2018, 179, 32-39.
226. Silaghi-Dumitrescu, Radu. Feudalism in Modern Eastern Europe. Balkanistic Forum, 2018, (1), 11-15.
225. Toma, Vlad Al.; Farcas, Anca D.; Roman, Ioana; Sevastre, Bogdan; Hathazi, Denisa; Scurtu, Florina; Damian, Grigore; Silaghi-Dumitrescu, Radu. In vivo evaluation of hemerythrin-based oxygen carriers: similarities with hemoglobin-based counterparts. International Journal of Biological Macromolecules 2017, 107, 1422-1427.
224. Lupan, Alexandru; King, R. Bruce; Silaghi-Dumitrescu, Radu. Tetracapped tetrahedral ruthenium-sulfur clusters related to iron-sulfur structural units in metalloenzymes. Inorganica Chimica Acta, 2018, 475, 193-199.
223. Mot, Augustin; C. Parvu, Marcel; Parvu, Alina E.; Rosca-Casian, Oana; Dina, Nicoleta E.; Leopold, Nicolae; Silaghi-Dumitrescu, Radu; Mircea, Cristina. Reversible naftifine-induced carotenoid depigmentation in Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison causing onychomycosis. Scientific Reports, 2017, 7(1), 11125.
222. Silaghi-Dumitrescu, Luminita; Attia, Amr A. A.; Silaghi-Dumitrescu, Radu; Blake, Alexander J.; Sowerby, D. Bryan. Supramolecular architecture of [AsPh2Br2]2[(Br3)-…(Br2)…(Br3)-] obtained by bromination of (AsPh2)2S. Inorganica Chimica Acta, 2018, 475, 120-126.
221. Hanganu, Dadniela; Benedec, Daniela; Vlase, Laurian; Olah, Noemi; Damian, Grigore; Silaghi-Dumitrescu, Radu, Moț, Augustin; Toma, C. Polyphenolic profile and antioxidant and antibacterial activities from two trifolium species. Farmacia, 2017, 65(3), 449-453.
220. Dereven'kov, Ilia; Ivlev, Pavel; Bischin, Cristina; Salnikov, Denis; Silaghi-Dumitrescu, Radu; Makarov, Sergei; Koifman, Oscar. Comparative studies of reaction of cobalamin (ii) and cobinamide (ii) with sulfur dioxide. Journal of Biological Inorganic Chemistry, 2017, 22(2), 969-975.
219. Silaghi-Dumitrescu, Radu. Arguable precedence for the World Wars of the XXth century. Social Evolution & History, 2018, 17(2), 96-108.
218. Bischin, Cristina; Attia, Amr A. A.; Silaghi-Dumitrescu, Radu. Chlorite reactivity with myoglobin: analogy with peroxide and nitrite chemistry? Journal of Inorganic Biochemistry, 2017, 172, 122-128.
217. Dereven’kov, Ilia A.; Ivlev, Pavel A.; Salnikov, Denis S.; Bischin, Cristina; Attia, Amr A. A.; Silaghi-Dumitrescu, Radu; Makarov, Sergei V. Studies of reaction of tetramethylthiourea with hydrogen peroxide: evidence of formation of tetramethylthiourea monoxide as a key intermediate of the reaction. Journal of Sulfur Chemistry 2017, 38(5), 496-509.
216. Silaghi-Dumitrescu, Radu; Mihály, Béla; Mihály, Timea; Attia, Amr A. A.; Sanz Miguel, Pablo J.; Lippert, Bernhard. The exocyclic amino group of adenine in Pt II and Pd II complexes: a critical comparison of the X-ray crystallographic structural data and gas phase calculations. Journal of Biological Inorganic Chemistry, 2017, 22(4), 567-579.
215. Toma, Vlad Al.; Farcas, Anca D.; Parvu, Marcel; Silaghi-Dumitrescu, Radu; Roman, Ioana. CA3 hippocampal field: cellular changes and its relation with blood nitro-oxidative stress reveal a balancing function of CA3 area in rats exposed to repeated restraint stress. Brain Research Bulletin, 2017, 130, 10-17.
214. Silaghi-Dumitrescu Radu. Fatalism and inaction associations with the Romanian Ballad of the Little Ewe. Venets: The Belogradchik Journal for Local History, Cultural Heritage and Folk Studies, 2016, 7(3), 332-341.
213. Arkosi, Mariann; Scurtu, Florina; Vulpoi, Adriana; Silaghi-Dumitrescu Radu; Kurtz, Donald M. Jr. Copolymerization of recombinant Phascolopsis gouldii hemerythrin with human serum albumin for use in blood substitutes. Artificial Cells, Nanomedicine, and Biotechnology 2017, 45(2), 218-223.
212. Attia, Amr A. A.; Cioloboc, Daniela; Lupan, Alexandru; Silaghi-Dumitrescu, Radu. Multiconfigurational and DFT analyses of the electromeric formulation and UVVis absorption spectra of the superoxide adduct of ferrous superoxide reductase. Journal of Inorganic Biochemistry, 2016, 165, 49-53.
211. Benedec, Daniela; Hanganu, Daniela; Oniga, Ilioara; Filip, Lorena; Bischin, Cristina; Silaghi-Dumitrescu, Radu; Tiperciuc, Brînduşa; Vlase, Laurian. Achillea schurii flowers: chemical, antioxidant, and antimicrobial investigations. Molecules, 2016, 21(8), 1050.
210.Attia, Amr A. A.; Silaghi-Dumitrescu, Radu . A mononuclear non-heme-iron dioxygen-carrying protein? Journal of Molecular Graphics and Modelling, 2016, 69, 103-110.
209. Szávuly, Miklós István; Surducan, Mihai; Nagy, Emőke; Surányi, Mátyás; Speier, Gábor; Silaghi-Dumitrescu, Radu; Kaizer, József. Functional models of nonheme diiron enzymes: kinetic and computational evidence for the formation of oxoiron(IV) species from peroxo-diiron(III) complexes, and their reactivity towards phenols and H2O2. Dalton Transactions, 2016, 45, 14709-14718.
208. Silaghi-Dumitrescu, Radu; Cioloboc, Daniela. Comparative computational characterization of ferric cytochrome P450 and superoxide reductase binding to cyanide. Studia Universitatis Babes-Bolyai Seria Chemia, 2016, 61(3), 45-54.
207. Benedec, Daniela; Popica, Iulia-Elena; Oniga, Ilioara; Hanganu, Daniela; Duma, Mihaela; Silaghi-Dumitrescu, Radu; Bischin, Cristina; Vlase, Laurian. Comparative HPLC-MS analysis of phenolics from Achillea distans and Achillea millefolium and their bioactivity. Studia Universitatis Babes-Bolyai Seria Chemia 2015, LX(4), 257-266.
206. Toma, Vlad Al.; Farcaș, Anca D.; Roman, Ioana; Sevastre, Bogdan; Hathazi, Denisa; Scurtu, Florina; Damian, Grigore; Silaghi-Dumitrescu, Radu. Comparative in vivo effects of hemoglobin-based oxygen carriers (HBOC) with varying prooxidant and physiological reactivity. PLoS One, 2016, 11(4): e0153909. doi:10.1371/journal.pone.0153909.
205. Lupan, Alexandru; Țolan, Roxana; Silaghi-Dumitrescu, Radu. Copper-porphyrins electronic structure with different axial ligands. Journal of the Chemical Society of Pakistan, 2016, 38(3), 405-414
204. Silaghi-Dumitrescu, Radu. Editorial: Inorganic biochemistry – a brief scientometric perspective with focus on eastern Europe and Romania. Acta Metallomica, 2014, XI(2), 3-14
203. Mocan, Andrei; Vlase, Laurian; Arsene, Andreea; Vodnar, Dan; Bischin, Cristina; Silaghi-Dumitrescu, Radu; Crisan, Geanina. HPLC/MS analysis of caffeic and chlorogenic acids from three Romanian Veronica species and their antioxidant and antimicrobial properties. Farmacia, 2015, 63(6), 890-896.
202. Tamaian, Radu; Moţ , Augustin C.; Silaghi-Dumitrescu, Radu; Ionuţ, Ioana; Stana, Anca; Oniga, Ovidiu; Nastasă, Cristina; Benedec, Daniela; Tiperciuc, Brîndușa. Study of the relationships between the structure, lipophilicity and biological activity of some thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles. Molecules, 2015, 22188–22201.
201. Benedec, Daniela; Hanganu, Daniela; Oniga, Ilioara; Tiperciuc, Brîndușa; Olah, Neli-Kinga; Raita, Oana; Bischin, Cristina; Silaghi-Dumitrescu, Radu; Vlase, Laurian. Assessment of rosmarinic acid content in six Lamiaceae species extracts and their antioxidant and antimicrobial potential. Pakistan Journal of Pharmaceutical Science, 2015, 28 (6(Suppl)), 2297-2303.
200. Dereven’kov, Ilia A.; Salnikov, Denis S.; Silaghi-Dumitrescu, Radu; Makarov, Sergei V.; Koiffman, Oscar I. Redox chemistry of cobalamin and its derivatives. Coordination Chemistry Reviews, 2016, 309, 68–83. DOI 10.1016/j.ccr.2015.11.001


Books
Radu Silaghi-Dumitrescu, Daniela Cioloboc. An introduction to bioinorganic chemistry, 2015, Presa Universitara Clujeana, Cluj-Napoca. (English)
Sergei V Makarov, Attila K Horvath, Radu Silaghi-Dumitrescu, Qingyu Gao. Sodium Dithionite, Rongalite and Thiourea Oxides, World Scientific, London, 2016, 244 pp, ISBN: 978-1-78634-095-5
Radu Silaghi-Dumitrescu, Daniela Cioloboc, Mariann Kinga Árkosi, Nicoleta Tomoioagă, Metalele in sistemele vii – ediția a II-a (Romanian), 2023, Presa Universitara Clujeana, Cluj-Napoca,
ISBN 978-606-37-1937-0
Vacancies and internships. Join us!
NEW: PhD and postdoc vacancies to be announced soon on our new research grant on platinum-based anticancer agents https://news.ubbcluj.ro/ubb-atrage-noi-cercetatori-de-top-din-strainatate-in-ubbmed-din-nou-cei-mai-multi-intre-universitatile-din-tara/

We always welcome students interested in studying and conducting scientific research. The steps below refer to unpaid internships, undergraduate diploma and MSc papers. Paid positions and scholarships are occasionally available (and will be advertised here) – though one should note that they are relatively rare and usually come on a very competitive basis.

1. If possible: talk to somebody already in the group and/or ask people from other groups about what you can expect. Look up the groups web page. Note that membership to the group entails as minimum requirements (1) attendance of weekly group meetings (where you would also have to participate in the discussions, discuss your progress over the past week, and occasionally give presentations), (2) attending, within reasonable limits, the scientific events (conferences, seminars) indicated/recommended in group meetings or in other communications within the group, (3) observe any other rules laid out in the group’s handbook.

2. Schedule a preliminary interview with prof. Radu Silaghi-Dumitrescu – either by stopping by room 80 or by messaging radu.silaghi@ubbcluj.ro

3. Prepare a motivation letter (at least one A4 page, Times New Roman 12, spaced at 1.5) describing your motivations and expectations regarding your research activity within the group, as well as further context (e.g., future plans)

4. Prepare a short essay (not shorter than 2 pages) expressing your opinions (including any possible criticisms) about the relevance and contributions of science (be they good or bad, small or large) in an event/topic of significant public interest – such as the COVID crisis, pollution, globalization, immigration, global warming, deforestation, vaccination, online culture (e.g., online teaching, social media etc), development of medical drugs, or any other topics (they can also be much narrower than the examples given above). Submit the letter and the essay to radu.silaghi@ubbcluj.ro and schedule an interview based on these, where decision on acceptance will be made.
The stopped-flow UV-vis facility
A stopped-flow UV-vis with diode array detector as well as monochromator, with freeze-quench capability, and with three-syringe sequential mixing capability (BioLogic, France), is available for use by interested researchers. The instrument is located in room 56 at the Faculty of Chemistry and Chemical Engineering @UBB, as part of the Center for Fundamental and Applied Heterochemistry.
Details
The manager of the stopped-flow facility is Prof Radu Silaghi-Dumitrescu. The team of authorized operating personnel includes researchers specialized in analytical chemistry, biochemistry and bioinorganic chemistry: assist. prof. Augustin Moț and PhD students Maria Lehene and Cezara Zăgrean-Tuza.
The main activities of the facility are research-related. Contract-based services are also welcome. Any interested parts are welcome to approach the laboratory director in order to discuss either line of collaboration. Prices for renting the facility, and/or for providing services, will be subjects of negotiation.
All BBU personnel may enjoy access to the facility, free of charge – pending a schedule approved by the laboratory director and with the actual measurements being performed by the core personnel. For more extensive collaborations, as well as for contracts/collaborations with third parties, protocols will be negotiated regarding the operator of the instrument, types of experiments and their length, costs, and other aspects.
Contact: .
Tel. + 40 264 593833, radu.silaghi@ubbcluj.ro

Read more about stopped-flow instruments
Laboratory of EPR spectroscopy
The laboratory’s main objective is research in the field of electron spin resonance/electron paramagnetic resonance. The target is advanced research with applications in materials science, physics, chemistry, biology, medicine, environment – using electron spin resonance / electron paramagnetic resonance (EPR, ESR), including pulsed procedures such as Electron Spin Echo Envelope Modulation (ESEEM), 2D HYperfine Sub-level CORrElation (HYSCORE), ENDOR, PELDOR as well as experiments at variable temperature (liquid nitrogen and helium).

Our team:
Prof. Radu Silaghi-Dumitrescu (chemistry/biochemistry)
Prof. Grigore Damian (physics/biophysics)
Prof. Vasile Miclăuș (chemistry)
Assist. Prof. Augustin Moț (chemistry/biochemistry)
PhD student Cezara Zăgrean-Tuza (biochemistry)
Details
The main activities of the Center are research-related. Contract-based services are also expected. Any interested parts are welcome to approach the laboratory director in order to discuss either line of collaboration.

All UBB personnel may enjoy access to the facility (ELEXSYS 580 and/or EMXmicro) free of charge with the measurements being performed by the core personnel. For more extensive collaborations, as well as for contracts/collaborations with third parties, protocols will be negotiated regarding the operator of the instrument, types of experiments and their length, costs, and other aspects.

Contact:
Radu Silaghi-Dumitrescu radu.silaghi@ubbcluj.ro
Grigore Damian, grigore.damian@ubbcluj.ro
Vasile Miclăuș, vasile.miclaus@ubbcluj.ro
Dr. Augustin Moṭ, augustin.mot@ubbcluj.ro
Read more about EPR spectroscopy
Outreach
Community/public outreach is something we care about. Here are some of the things we have done about it.

On the role of science in society
An interview on the experience of coming back from the diaspora: PressOne, 2015: http://pressone.ro/trenul-de-sarajevo-si-repatrierea-academica-din-diaspora/
Opinion piece on the public debate regarding nonconform biocides in hospitals from
Hexi Pharma: Romania Curata, 2017: http://www.romaniacurata.ro/fara-dovezi-materiale-pentru-diluarea-de-zece-ori-a-dezinfectantilor-hexi-pharma/
Take SARS-CoV2 seriously: Adevărul 2020 https://adevarul.ro/locale/cluj-napoca/cercetator-celebru-ubb-cei-spun-virusul-exagerare-fac-propaganda-crima-1_5ef70cc75163ec42715f690a/index.html
Political correctness:
contributors.ro 2021, https://www.contributors.ro/corectitudinea-politica-cand-esti-nemernic-si-mandru-de-asta/
On the undue silence of the Romanian science institutions on scientific topics - COVID and otherwise:
contributors.ro 2021, https://www.contributors.ro/sa-ascultam-institutiile-de-stiinta-din-romania-spunand-ce/
An analysis of the scientific grounds of the COVID restrictions in Romania:
contributors.ro 2021, https://www.contributors.ro/masurile-anti-covid-din-romania-ce-ne-permite-stiinta-sa-criticam-sau-despre-romania-educata/
On the dismal profile of science in Romanian society:
contributors.ro 2021, https://www.contributors.ro/orfani-de-stiinta/
On the magnitude of unreported COVID cases in Romania: contributors.ro 2021, https://www.contributors.ro/imunizarea-inainte-de-valul-4-optimismul-n-ar-trebui-interzis/
On the strategy of the anti-COVID vaccination campaign in Romania:
contributors.ro 2021, https://www.contributors.ro/vaccinarea-restrictii-recompense-sau-altceva/
On the undue silence of Romanian universities regarding COVID vaccinationŁ
contributors.ro 2021, https://www.contributors.ro/cum-tac-universitatile-din-romania-despre-vaccinare/
A case where chemistry is relevant for foreign politics - Afghanistan: contributors.ro 2021, https://www.contributors.ro/chimia-afganistanului-cand-alegerea-e-intre-doua-crime/
Romania at the end of COVID restrictions - what have we done and could we have done more? contributors.ro 2022, https://www.contributors.ro/legatura-dintre-romania-educata-si-sfarsitul-dictaturii-medicale/
Sign of the times: rising tide of extreme discourse in (and on) Romanian academia on the topic of plagiarism. Whistleblowers under siege: contributors.ro 2022, https://www.contributors.ro/razboiul-din-ucraina-e-in-primul-rand-unul-impotriva-decentei-cu-un-ecou-in-mediul-academic/
Ignoring plagiarism for high officials: Russia has long set the standards. Romania should stop following: contributors.ro 2022, https://www.contributors.ro/musamalizarea-plagiatelor-la-nivel-inalt-nu-intareste-romania-in-contextul-agresiunii-rusiei-ci-transforma-romania-in-rusia/
Can Artificial Intelligence really write scientific papers yet? Not really: contributors.ro 2023, https://www.contributors.ro/universitatile-amenintate-de-inteligenta-artificiala/
A computational analysis of national anthem texts: contributors.ro
https://www.contributors.ro/regele-comunistii-si-sangele-roman-spune-ceva-despre-noi-un-imn-national-schimbat-de-un-numar-record-de-ori/
Open Access journals https://www.hotnews.ro/stiri-opinii-26899042-revolutie-bolsevica-stiinta-open-access.htm

Public lectures
Two TEDx talks on blood substitute development: https://www.youtube.com/watch?v=fS4PZuyuWiY&t=26s&ab_channel=TEDxTalks and https://www.youtube.com/watch?v=s9MNWUTcteY&ab_channel=TEDxTalks
Measuring the science - on bibliometrics and the Leiden Manifesto: https://www.youtube.com/watch?v=FUimXIqjlEw&ab_channel=Enformation.ro
Metals in living systems: https://www.youtube.com/watch?v=7x1N5gmNiHs&ab_channel=UniversitateaBabe%C5%9F-Bolyai

The uniMIND journal club at Cluj-Napoca
The MIND Foundation is a European non-profit science and education organization that promotes psychedelic research and therapy. Related to this, Prof. Silaghi-Dumitrescu has co-tutored the uniMIND student journal club at Cluj-Napoca; you may watch their meetings online https://www.youtube.com/results?search_query=unimind+cluj-napoca

On pseudoscience
How vaccination campaigns gone wrong can now fuel COVID conspiracy theories: contributors.ro 2021, https://www.contributors.ro/pandemia-care-n-a-fost-si-vaccinurile-care-nu-trebuiau-1976-plus-vaccinurile-pentru-sterilizare/
On some not-so-scientifically-grounded myths regarding healthy living: contributors.ro 2021, https://www.contributors.ro/ce-sa-faci-zilnic-pentru-o-viata-sanatoasa/
UBB's manifesto against pseudo-therapies and pseudoscience: https://cercetare.ubbcluj.ro/ro/manifest-asupra-pseudo-terapiilor/
Do Romanians really have an unusual history of killing their leaders? Matricea Românească, 2018, https://matricea.ro/mitul-freneziei-regicide-printre-valahi-o-replica-la-afirmatia-lui-georg-reicherstorffer-despre-romani-si-asasinate-politice/
Measuring pseudoscience in Romanian mass-media: https://www.youtube.com/watch?v=VK_mb2iAl-M&t=32s&ab_channel=TVRCluj
What to do about overhyped advertisements regarding food and vityamin/mineral supplements?
https://www.contributors.ro/ar-trebui-interzise-reclamele-exagerate-la-suplimente-alimentare-si-produse-naturiste/

Our research in the news
Our blood substitute project has received some attention in the news - though most such reports were arguably in extensive breach of professional ethics by the respective journalists. Here is a somewhat more accurate report: https://www.smithsonianmag.com/innovation/a-romanian-scientist-claims-to-have-developed-artificial-blood-180947565/
Our report on the cobalamin reaction with hydrogen peroxide: https://news.doctorat.ubbcluj.ro/2021/08/20/vitamin-b12-and-hydrogen-peroxide-secret-unveiled-by-ubb-researchers/
Our report on the Dyes and Pigments paper:
https://news.doctorat.ubbcluj.ro/2022/08/08/vibrating-blue-at-ubb-new-derivatives-and-new-near-infrared-light-on-150-year-old-pigment-with-medical-relevance/
Our report on the iodine-starch reaction:
https://news.doctorat.ubbcluj.ro/2022/12/20/why-so-blue-new-explanation-for-the-well-known-iodine-starch-reaction-in-chemistry/
Our work on automated text analysis of national anthems:
https://www.hotnews.ro/stiri-opinii-26784102-regele-comunistii-sangele-roman-spune-ceva-despre-noi-imn-national-schimbat-numar-record-ori.htm, Romanian Science Digest
Our new grant on anticancer drugs with prof. Hey-Hawkins
https://news.ubbcluj.ro/ubb-atrage-noi-cercetatori-de-top-din-strainatate-in-ubbmed-din-nou-cei-mai-multi-intre-universitatile-din-tara/
Our iodine-starch research, featured on a recent episode of ACS Chemical Reactions produced in partnership with PBS Digital Studios Can science beat counterfeit detector pens?
News
16.02.24 - new article by prof. Silaghi-Dumitrescu on Open Access journals https://www.hotnews.ro/stiri-opinii-26899042-revolutie-bolsevica-stiinta-open-access.htm

06.02.24 - new paper out by dr. Brânzanic - The effect of precipitation conditions on the morpho-structural and optical properties of some zinc oxidic based compounds in the Journal of Sol-Gel Science and Technology

05.02.24 - our iodine-starch research, featured on a recent episode of ACS Chemical Reactions produced in partnership with PBS Digital Studios Can science beat counterfeit detector pens?

01.02.24 - new papers: a small contribution from us to a paper of our organic chemistry colleagues at UBB: Outcomes of folic acid esterification upon the properties of hydrophilic phenothiazinium dyes: New photosensitizers for antimicrobial photodynamic therapy. Journal of Photochemistry and Photobiology A: Chemistry, 2023, 115500, and a review on the iodine-iodide-amylose/starch color reaction by Szilárd Pesek: The Iodine/Iodide/Starch Supramolecular Complex. Molecules, 2024, 29(3), 641

30.01.24 - two Excellence Awards from the UBB to prof Silaghi-Dumitrescu for his presence in the top 2% rankings of researchers throughout all research fields as well as in the field of inorganic chemistry, based on results/citations throughout the career

09.01.24 - new student in the group - Andrea Incze. Also, new paper out from prof Silaghi-Dumitrescu: The King, the Communists and the Roman Blood: An Automated Analysis of the Romanian National Anthems, Proglas, 2023, 32(2), 147-157. https://doi.org/10.54664/GGAE2354, covered in an essay for national commentary site contributors.ro - https://www.contributors.ro/regele-comunistii-si-sangele-roman-spune-ceva-despre-noi-un-imn-national-schimbat-de-un-numar-record-de-ori/ . Also recently out: the second edition in Romanian of our bioinorganic chemistry textbook "Metals in living systems" free to download from the publisher. Also: new research grant starting soon, on Pt-based anticancer agents - with vacancies open for hiring!

08.12.23 - public defense of PhD thesis by Szilárd Pesek, 10 AM at the Faculty of Chemistry

04.12.23 - MSc student Nicoleta Andrian joins the group. Also, our new paper is out, on the structure of poly-lactic acid, dedicated to prof. Bogdan Simionescu's 75th anniversary - and a cover picture in Revue Roumaine de Chimie

21.11.23 - MSc student Radu Onija has joined the group

21.11.23 - new paper from us - employing hemoprotein redox chemistry and free radical detection with EPR for assessing natural products / extracts - Stachys Species: Comparative Evaluation of Phenolic Profile and Antimicrobial and Antioxidant Potential

14.11.23 - new paper from us - Theodor Danescu et al., Theoretical Study of the Effect of Phosphorus and Nitrogen Heteroatoms on Pentahapto Coordination of Diazaphospholyl Ligands in Binuclear Ruthenium and Iron Carbonyl Derivatives. Journal of Organometallic Chemistry, 2023, 122949 in the Journal of Organometallic Chemistry

21.10.23 - new paper from us - Study of cobalamin adducts with cysteine and its oxidized sulfenic, sulfinic and sulfonic derivatives in Revue Roumaine de Chimie by Artiom Gaina-Gardiuta, Alexandru Lupan, Adrian M. V. Brânzanic, Radu Silaghi-Dumitrescu

13.10.23 - two new papers from us - Coman, Cristina; Hadade, Niculina; Pesek, Szilard, Silaghi-Dumitrescu, Radu; Mot, Augustin C. Removal and degradation of sodium diclofenac via radical-based mechanisms using S. sclerotiorum laccase. Journal of Inorganic Biochemistry, 2023, 112400. https://doi.org/10.1016/j.jinorgbio.2023.112400, Fischer-Fodor, Eva; Szabo, Kinga; Scurtu, Florina; Lehene, Maria; Silaghi-Dumitrescu, Radu. Toxicity of hemoglobin derivatized with oxidized adenosine triphosphate against tumoral human cells. Studia UBB Chemia, 2023, LXVIII(3), 153-160. DOI:10.24193/subbchem.2023.3.10.

13.10.23 - Dipa moves to the Institute of Chemistry @UBB to study dental materials with dr. M. Moldovan's group. Theodor's main project is now under the direction of dr. Vlad Cojocaru @UBB.

21.09.23 - lecture by prof. Radu Silaghi-Dumitrescu at the conference New Trends in Chemistry Research - 2023 edition, September 21-22, 2023, Timișoara, România https://www.newtrends-timisoara.ro/ ; poster by Maria Lehene at the annual international conference of Romanian Society for Biochemistry and Molecular Biology https://biogeo.ubbcluj.ro/RSBMB/ ; Adrian Branzanic on a research visit to the Srnec group at the J. Heyrovský Institute of Physical Chemistry in Prague; Cezara Zagrean-Tuza starts a Fulbright fellowship with the Green group at the University of California, Irvine; new people in the group - MSc student Alex Sonica, PhD students Theodor Danescu and George Vaida

07.09.23 - new paper from us: Lehene, Maria; Zagrean-Tuza, Hadade, Niculina; Cezara; Aghion, Andreea; Septelean, Raluca; Iancu, Stefania; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. A complex of cobalamin with an organic peroxide. New Journal of Chemistry, 2023, https://doi.org/10.1039/D3NJ03307D

27-31.08.23 - group trip to the 14th EuChemS CompChem conference - with prof. Silaghi-Dumitrescu, Adrian Branzanic and Theodor Danescu.

11.08.23 - new paper from us: Silaghi-Dumitrescu, Radu. Trends in the Texts of National Anthems: A Comparative Study. Heliyon, 2023 e19105. https://doi.org/10.1016/j.heliyon.2023.e19105

30.07.23 - a few more papers from us: Silaghi-Dumitrescu, Radu; Patrascu, Iulia; Lehene, Maria; Bercea, Iulia. Comorbidities of COVID-19 Patients. Medicina, 2023, 59(8), 1393. https://doi.org/10.3390/medicina59081393. Doukeh, Rami; Craciun, Daniela; Lupan, Alexandru; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. Effect of the coordination environment on the ability of iron to bind/activate N2: a theoretical study with relevance to the nitrogenase mechanism. Polyhedron, 2023, 116571. DOI: 10.1016/J.POLY.2023.116571. Lehene, Maria; Brânzanic Adrian M.V.; Silaghi-Dumitrescu, Radu. The adducts of cyano- and aquacobalamin with hypochlorite. Journal of Biological Inorganic Chemistry, 2023, doi: 10.1007/s00775-023-02015-z.

16-21.07.23 - prof. Silaghi-Dumitrescu and dr. Branzanic gave presentations at ICBIC20 - The Twentieth International Conference on Biological Inorganic Chemistry in Adelaide, Australia

04.07.23 - a few papers our from us: Plesa, Diana; Lehene, Maria; Silaghi-Dumitrescu, Radu. On the reaction of Co(II) cobalamin with hydrogen peroxide. Reaction Kinetics, Mechanisms and Catalysis, 2023, https://doi.org/10.1007/s11144-023-02441-9, Branzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu. Quale Mechanics as a Metaphysical Weltanschauung of Quantum Mechanics. History of science and technology, 2023, 13(1), 10-33, DOI: 10.32703/2415-7422-2023-13-1-10-33, Arkosi, Mariann-Kinga; Mot, Augustin C.; Lupan, Iulia; Ghinia Tegla, Miruna Georgiana; Silaghi-Dumitrescu, Radu. Selective attachment of polyethylene glycol to hemerythrin for potential use in blood substitutes. Protein Journal, 2023, https://doi.org/10.1007/s10930-023-10118-4

04.07.2023 - graduation week @UBB for our MSc students Diana Plesa and Victoria Cirjeu - wishing them all the best as they leave the group

26.06.-01.07.2023 - Adrian Branzanic attending ICQC 2023 in Bratislava

30.06.2023 - prof. Silaghi-Dumitrescu delivering an invited presentation at Consiliul Național de Statistică și Prognoză a Învațământului Superior (CNSPIS), Workshop “Rankinguri Internaționale Utilizate în Metarankinguri”, Oradea, Romania - on the topic of international university rankings

19.06-23.06.2023 - Prof. Silaghi-Dumitrescu teaching and delivering a presentation at the EUTOPIA Doctoral Summer School held in Lison (Nova University), Portugal - http://eutopiadoctoralsummerschool.unl.pt/edss.html

01.06-03.06.2023 - Szilard Pesek attending the 4th Young Researchers' International Conference
on Chemistry and Chemical Engineering (YRICCCE IV) in Debrecen

26.04-30.04.2023 - Lavinia Padurean and Sergiu-Raul Cosma attending the International Conference ”Students for Students” in ClujNapoca; prof. Silaghi-Dumitrescu delivering an invited lecture
Learn more
Other resources

The MolMod lectures

The MolMod Lectures are a series of research-informed on-line and/or hybrid tutorials initiated in 2022 and focused on topics related to Molecular Modeling in Chemistry and Biochemistry. This series of lectures is an extension of the homonymous conference series and MSc programme hosted by the Babeș-Bolyai University (UBB) via its Faculty of Chemistry and Chemical Engineering since 2007. The expected target will be the students registered for the MolMod MSc programme at UBB, as well as the general audience typically found at the MolMod conference series.

http://chem.ubbcluj.ro/molmod_lectures/


Resources for students

Beginner's hints for preparing your scientific report (Romanian)

Beginner's hints for preparing your dissertation defense "PowerPoint" presentation (Romanian)


Some of our favorite links:

Molecular Modeling in Chemistry and Biochemistry Conference

Faculty of Chemistry and Chemical Engineering @UBB

Babeș-Bolyai University

The Scientific Council of the Babeș-Bolyai University

Division of Computational and Theoretical Chemistry (DCTC) @ the European Chemical Society (EuChemS)

PhD News @ UBB

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