Cosma, S.-R., Gorgan, D., Brânzanic, A. M. V. & Silaghi-Dumitrescu, R. No heme-chlorite adduct in the catalytic cycle of chlorite dismutase: Insight from QM / MM and dynamics calculations. J. Inorg. Biochem. 280, 0–5 (2026).
doi:10.1016/j.jinorgbio.2026.113312
Williams, L. J. et al. Can ferric-oxyl excited states explain elongated iron-oxygen bonds in heme peroxidase catalytic intermediates? Nat. Commun. 17, 1–14 (2026).
doi:10.1038/s41467-026-69192-8
Onija, R. I., Cosma, S. R., Brânzanic, A. M. V. & Silaghi-Dumitrescu, R. Rationales for the Choice of Metals for Super-Reduced Biological Metal Centers: Cobalt in Cobalamin Versus Nickel in F430. Chem. - A Eur. J. 1–6 (2026)
doi:10.1002/chem.71214
Zagrean-Tuza, C., Lehene, M., Sonica, A. & Silaghi-Dumitrescu, R. Bioorganometallic Chemistry and Super-Reduced Biological Metal Centers. Rev. Roum. Chim. 70, 769–779 (2025).
doi:10.33224/rrch.2025.70.11-12.04
Cîrjeu, V., Andrian, N., Puşcaş, C., Zagrean-Tuza, C. & Silaghi-Dumitrescu, R. Dacarbazine affects the redox reactivity of hemoglobin. J. Porphyr. Phthalocyanines 29, 958–965 (2025).
doi:10.1142/S1088424625500725
Stoean (Vasile), B. et al. Photosensitizer activity of phenothiazinium derivatives against melanoma cells and DFT insights into singlet oxygen generation. Bioorg. Chem. 163, 108720 (2025).
doi:10.1016/j.bioorg.2025.108720
Cosprundan, A. M. et al. Influence of the second coordination sphere on the autooxidation reaction in oxygen-binding proteins. Rev. Roum. Chim. 70, 313–327 (2025).
doi:10.33224/rrch.2025.70.5-6.08
Lehene, M. et al. The chlorite adduct of aquacobalamin: contrast with chlorite dismutase. J. Biol. Inorg. Chem. 30, 25–34 (2025)
doi:10.1007/s00775-025-02100-5
Andrian, N. et al. Controlling the biologically relevant reactivity in coumarin derivatives : from antioxidant to prooxidant to dna toxicity in two 5 , 7-dihydroxy-2h-chromen-2-one derivatives. Rev. Roum. Chim. 70, 421–433 (2025)
doi:10.33224/rrch.2025.70.7-8.06
Maria Lehene, Jozsef Simon, Cezara Zagrean-Tuza, Andreea Aghion, Bianca Vasile, Alexandru Sonica, Stefania Iancu, Radu Silaghi-Dumitrescu. Oxygen-carrying proteins employed in blood substitute candidates: differences in interactions with a model antioxidant molecule. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, 2025, 141086.
doi.org/10.1016/j.bbapap.2025.141086
Zagrean-Tuza, Cezara; Padurean, Lavinia; Lehene, Maria; Branzanic, Adrian; Silaghi-Dumitrescu, Radu. Globin ferryl species: what is the nature of the protonation event at pH < 5?
Journal of Biological Inorganic Chemistry, 2025
doi.org/10.1007/s00775-024-02089-3
Zagrean-Tuza, Cezara; Igescu, Ilinca; Lupan, Alexandru; Silaghi-Dumitrescu, Radu. A study of the molecular interactions of hemoglobin with diverse classes of therapeutic agents.
Inorganica Chimica Acta, 2024
doi.org/10.1016/j.ica.2024.122053
Zăgrean-Tuza, C., Matei, A., Silaghi-Dumitrescu, R. A biomimetic assay for antioxidant reactivity, based on liposomes and myoglobin
Journal of Inorganic Biochemistry 258 (2024): 112613
doi.org/10.1016/j.jinorgbio.2024.112613
Sonam, S., Moji, M., Gordi, V., Nicoara, A. & Gaina, L. Novel Ruthenacarborane – NSAID Conjugates. 1–20 (2025)
doi:10.3390/molecules30214153
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál and Luiza Gaina.
meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells.
RSC Medicinal Chemistry, 2024,
doi.org/10.1039/D4MD00601A
Ueberham, L. et al. Carborane-Based Analogs of Celecoxib and Flurbiprofen, their COX Inhibition Potential, and COX Selectivity Index. ChemMedChem 20, 11–14 (2025).
doi:10.1002/cmdc.202500166
Selg, C. et al. Advances in Diclofenac Derivatives: Exploring Carborane-Substituted N-Methyl and Nitrile Analogs for Anticancer Therapy. ChemMedChem 20, (2025).
doi:10.1002/cmdc.202500084
Richter, S., Dimić, D., Lönnecke, P., Kaluđerović, G. N. & Hey‐Hawkins, E. Comparative Study of Platinum(II) and Platinum(IV) Complexes with 2‐(Pyridin‐2‐ylmethylamino)acetic Acid and 4‐(Pyridin‐2‐ylmethylamino)benzoic Acid: Experimental and Theoretical Analysis. ChemistryEurope 3, (2025).
doi:10.1002/ceur.202500049
Ueberham, L., Kazimir, A., Deuther-Conrad, W. & Hey-Hawkins, E. Development of Carborane-Based Benzothiazole Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands. ACS Omega 10, 38264–38271 (2025).
doi:10.1021/acsomega.5c06508
Ueberham, L., Deuther-Conrad, W., Lönnecke, P., Kazimir, A. & Hey-Hawkins, E. Development of Carborane-Based Halogenated Naphthyridinone-Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands. ChemMedChem 20, (2025)
doi:10.1002/cmdc.202500251
Wonneberger, P., Keil, L., Spickenreuther, P., Lönnecke, P. & Hey-Hawkins, E. 1-Phospha-2-Azanorbornene As Precursor for 1-Phospha-Bicyclo[3.2.1]Octa-2,5-Diene. Stud. Univ. Babes-Bolyai Chem. 70, 293–299 (2025)
doi:10.24193/subbchem.2025.4.17
Kuhnert, L. et al. Polymethoxylated N-Carboranyl Isoquinolinones: A New Scaffold for ABCG2 Inhibitors. ChemMedChem 21, 1–16 (2026).
doi:10.1002/cmdc.202500708
Schädlich, J. et al. Radioiodination of Two Carborane-Based Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation. ChemBioChem 27, 1–18 (2026)
doi:10.1002/cbic.202600004
Selg, C., Sauerwein, W. A. G. & Hey-Hawkins, E. Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT). Med. Res. Rev. (2026)
doi:10.1002/med.70060
Schädlich, J. et al. An Approach Toward Radioiodination and Radiopharmacological Evaluation of a Carborane-Containing Analog of Indomethacin. Molecules 31, 1–30 (2026).
doi:10.3390/molecules31111944
Conferences
17th European Biological Inorganic Chemistry Conference (EuroBIC-17), Muenster, August 25-29, 2024
Radu Silaghi-Dumitrescu - Beyond the coordination chemistry of metal-corrin / cobalamin derivatives with oxidizing agents: exploring the scope and the physiological relevance (lecture)
Alexandru Sonica - Binding of biomedically relevant agents to hemoglobin (poster)
Konferenzen
17th European Biological Inorganic Chemistry Conference (EuroBIC-17), Muenster, August 25-29, 2024
Radu Silaghi-Dumitrescu - Beyond the coordination chemistry of metal-corrin / cobalamin derivatives with oxidizing agents: exploring the scope and the physiological relevance (vorträge)
Alexandru Sonica - Binding of biomedically relevant agents to hemoglobin (poster)
19th Central European Seminar on Theoretical Chemistry CESTC, Croatia, September 11-14, 2024
Radu Silaghi-Dumitrescu - Activation of molecular nitrogen and of protons at biological metal centers (poster)
The 16th Edition of the International Conferince New Trends in Chemistry, Research. Timisoara September 18-20, 2024.
Evamarie Hey-Hawkins, Metal-based anticancer drugs for selective tumour-targeting (vorträge)
Radu SILAGHI-DUMITRESCU - Binding of biomedically relevant agents to hemoglobin and related proteins (vorträge)
Romanian national chemistry conference CNCHIM, XXXVII Edition, Targoviste, September 25-27, 2024
Radu Silaghi Dumitrescu - Synergy between computations and experiments on transition metal complexes: Challenges with isomerism, spin states and spectroscopy (vorträge)
Alexandru Sonica, Jozsef Simon, Maria Lehene, Radu Silaghi-Dumitrescu - Binding biomedically relevant agents to hemoglobin (vorträge)
Nicoleta Andrian - Candidates and precursors for anticancer drug (poster)
Maria Lehene - (poster)
Bianca Vasile (Stoean), Alexandru Sonica, Maria Lehene, Luiza Gaina, Radu Silaghi-Dumitrescu, Evamarie Hey-Hawkins - Development and characterization of new platinum(IV) Complexes with carboxylic or phenolic ligands: Synthesis, structural insights, and computational Studies (Poster OBFC-P21)
International Conference on Chemistry XXX edition. Cluj Napoca October 23-26, 2024.
