Objectives
Objective
1 aims the generation of selective
MNPs as support for enzymes (including new production methods to gain improved
properties.
Objective
2 will develop selective MNPs-based
enzyme immobilization methods (including novel-affinity based immobilization
methods or a combination of physical entrapment or adsorption and covalent
binding on surface of some stereoselective
transaminases with R- and S-selectivity, isolated from different
natural sources, with improved stability).
|
A |
B |
D C |
|
The enzyme molecules
arrangement in immobilized biocatalysts in case of (A) entrapment; (B)
mesoporous carrier; (C) nanoparticles. Magnetic nanoparticles (D) enable easy
separation.
Objective
3 will result in novel MNPs-based
microfluidic systems for pilot-lab scale production (use of nanoscale
immobilization methods to in new continuous-flow setups to achieve pilot-lab
scale production).
Prototype of a multi-magnetic cell microreactor for continuous-flow enzyme reactions
Objective 4 intends to upscale the newly developed biocatalysts based applications to pilot-lab scale synthesis of various amine enantiomers as chiral building blocks for the synthesis of bioactive molecules.
High-value
active pharmaceutical ingredients (APIs) containing chiral amine or amino acid
structural elements