Web of knowledge for

NANOSILVA

Contract number 83/2017

National Authority: UEFISCDI

UNIVERSITATEA BABES BOLYAI

FACULTATEA DE CHIMIE SI INGINERIE CHIMICA

Innovative composites with antimicrobial properties comprising ceramic nanoparticles and silver nanoparticles, functionalized with biomolecules, embedded into polymer matrix

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·   Project objectives

Main objective

The objective of NanoSilva project is the development of new advanced nanomaterials, combining the effect of silver nanoparticles and organic antimicrobial biomolecules against pathogenic microorganisms with the effect of nano hydroxyapatite on osteogenic differentiation of human stem cells, for biomedical use in bone repair and regeneration.

The specific objectives:

The major objective of this project is the development of novel synthesis strategies to obtain the narrow size distribution of AgNPs. Then, an important objective is the functionalization of AgNP surface with biomolecules, such as antibiotics or antimicrobial compounds (AMC), by adsorption and self-assembly approach.

Another major objective is centred on the development of advanced nanomaterials based on AgNPs and nano hydroxyapatite (HAP), either by their mixture at various concentrations, resulting AgNPs/HAP nanomaterials, or by the direct synthesis of AgNPs on HAP particles (AgNPs-AMC) with their improved antimicrobial effect on pathogenic microorganisms as well as with enhanced effect on osteogenic differentiation of human stem cells, having impact on bone regeneration, as evidenced in our preliminary experiments.

Antimicrobial characterization of the new advanced NanoSilva composites is one of the most important specific objectives with impact in the identification of applicability field. The antimicrobial behavior as well as bone regeneration in presence of AgNPs and HAP mixtures will be followed within this specific objective.